Shimbhala Curcumin - Pure Turmeric Curcumin Extract
Curcumin – Curcuma longa L (turmeric) is cultivated in tropical and subtropical regions. The largest worldwide producer of turmeric is India, where it has been used as a home-remedy for several ailments for all ages. Depending on its origin and the soil conditions where it is grown, turmeric contains 2%–9% curcuminoids. The word “curcuminoid” indicates a group of compounds such as curcumin,demethoxycurcumin and bis-demethoxycurcumin and cyclic curcumin. Out of these, curcumin is the major component, and cyclic curcumin is the minor component.
Curcumin is a specially gifted molecule provided by Mother-Nature to protect humans from chronic health problems. Looking at the simple chemical structure of curcumin, it is natural to presume that chemistry of curcumin is also very simple, however with increasing scientific understanding it appears to be more complex, unique and difficult to comprehend. It is a symmetric molecule abundant in turmeric with relatively high stability in natural form. It has an intense yellow color, that changes to deep red in basic pH solution.
In simple aqueous and aqueous-organic solutions, it is susceptible to fast degradation, which increases as the basicity of the solutions increases, and also on exposure to sunlight. The metabolic products of curcumin are different from the degradation products, where O-conjugation and reduction are the important processes initiated through the enzymatic reactions. Interestingly unlike the degradation products, the metabolic products are much more difficult to synthesize in the laboratory.The presence of α,β-unsaturated structure makes curcumin participate in nucleophilic addition reactions with protein thiols and selenols, that play important role in modulating cellular oxidative stress. It is still not clear if these processes are reversible under physiological conditions. Recently there is a surge of activity on preparation and characterization of curcumin-metal complexes due to the strong affinity of β-diketo moiety as an efficient metal chelator.
Although it is confirmed that curcumin reduces metal toxicity in living systems through complexation, the actual role of these metal complexes in curcumin biology appears to be complex and unclear. Detailed research is warranted on structure-activity evaluation of the curcumin-metal-complexes in solution. Problems associated with curcumin bioavailability could be overcome to a great extent through formulations with natural biopolymers, which find practical application as nutritional products. Recent research is now focused on developing conjugates of curcumin with metal and metal oxide nanoparticles and some of these formulations have promising potential in nanomedicine with additional effects of inducing targeted hyperthermia in cancer cells. They are also attracting interest as diagnostic tools for Alzheimer’s disease and also as MRI contrast agents. Overall a great deal of studies already done reveal conclusively the therapeutic effects of Curcumin as a divine natural product and as a therapeutic remedy for many chronic diseases.
A large number of studies have revealed that curcumin has wide therapeutic actions such as antiinflammatory, antispasmodic,antimicrobial, anticancer, antistroke, hepatoprotection and neuroprotection etc. Curcumin has been shown to possess significant anti-inflammatory, anti-oxidant, anti-carcinogenic, anti-mutagenic, anti-coagulant and anti-infective effects. It has recently shown to exhibit epigenetic modulatory properties.
Inflammation is a normal protective response to tissue injury that is caused by physical trauma, noxious chemicals or microbiological agents. Inflammation is the result of concentrated participation of more number of proliferative factors at different stages and there are many targets for anti-inflammatory activity.
Curcumin’s antiinflammatory activity is mainly due to inhibition of AA metabolism, COX, LOX, cytokines (ILs and TNF) and NF-B. Curcumin is reported to stabilize lysosomal membrane and causes uncoupling of oxidative phosphorylation besides having strong oxygen radical scavenging activity.
The most interesting feature of curcumin is lack of gastrointestinal side effects despite being an anti-inflammatory agent. Thus curcumin may prove as a useful drug for treatment of critical diseases such as arthritis, cancer, HIV etc.
When And Who Should Use Shimbhala Curcumin
Please note: Since Curcumin is found to be an anti-inflammatory with clinically tried and studied ability to inhibit disease carrying cell pathways, it has been found to be effective in the treatment of many diseases which are listed under
- In healthy individuals Curcumin works as an anti cancer agent. Inflammation is the basic cause of diseases such as in most types of cancer, cardiovascular disease, arthiritis, nero disorders etc. Curcumin tackles inflammation in the body and finally finishes it thereby we can safely use Curcumin for decreasing the chances of cancer incidence.
- Curcumin is a potential cancer chemopreventive agent. Curcumin is effective in the treatment of tumours. It can be used as a long term preventive anti-inflammatory without any side effects which is the greatest aspect of curcumin.
- Cardiovascular disease- Curcumin reduces chances of stoke or clotting because of it’s anti-coagulant action. Arthescelerosis can be prevented if inflammation is controlled.
- Useful in the treatment of ulcerative proctitis, Crohn’s disease, ulcerative colitis, peptic ulcer, gastric ulcer, idiopathic orbital inflammatory pseudotumor, oral lichen planus, gastric inflammation, vitiligo, psoriasis, acute coronary syndrome.
- Useful in the treatment of β-thalassemia, biliary dyskinesia, Dejerine-Sottas disease, cholecystitis, and chronic bacterial prostatitis.
- People suffering from Neurological disorders
- People suffering from Alzheimer’s disease (AD) and Parkinson’s disease.
- People with Inflammatory diseases such as Cardiovascular disease, irritable bowel syndrome, Rheumatoid Arthiritis, chronic bronchial disease, Asthma, sinusitis etc.
- People with tooth and oral diseases such as irritable and swollen or sensitive gums/teeth.
- People with Fatty Liver.
- People with gastrointestinal diseases.
- Curcumin is a Preventive agent in acute pancreatitis.
- People suffering from varicose veins.
- People suffering from chronic anterior uveitis
- People suffering from edema,skin allergies and skin or epidermal disorders and allergic encephalomyelitis.
- Curcumin can be used for Skin regeneration and Wound healing.
- Useful for people suffering from Anorexia Nervosa
- Useful for people suffering from chronic cough and sinusitis
- Useful in the treatment of sciatica.
- Curcumin has beneficial effects on several ocular diseases, such as chronic anterior uveitis, diabetic retinopathy, glaucoma, age-related macular degeneration, and dry eye syndrome.
- As a strong antioxidant Curcumin strengthens the immune system immensely and facilitates the human body to resist disease and infections.