Curcumin Clinical studies
Curcumin – Resource Database
Anil Kumar,1,2 Hasnahana Chetia,1 Swagata Sharma,1 Debajyoti Kabiraj,1 Narayan Chandra Talukdar,3,*and Utpal Bora1,4,*
This article has been cited by other articles in PMC
Curcumin (diferuloylmethane) is a hydrophobic polyphenol derived from rhizome of the perennial herb turmeric (Curcuma longa) which belongs to the ginger family (Zingiberaceae) native to tropical South Asia. Numerous traditional usage of turmeric is described in Indian and Chinese traditional medicine for prevention and treatment of a broad spectrum of diseases and conditions. These uses include turmeric pastes for treating eye infections, burns and bruises; turmeric powder with milk for respiratory ailments; and roasted turmeric for dental and digestive disorders. With the advent of western medicine, the use of turmeric for medication went into oblivion for a long time. However, record of more than 13,000 scientific articles published during the last three decades suggests that there is a renewed interest in turmeric and its principal therapeutic component, curcumin.
This research in curcumin and its analogs (curcuminoids) is focused on exploring their potential use as antimicrobial, antioxidant, anti-inflammatory, onco- preventive, neuro-regenerative agents and other health benefits. Curcumin has been found effective in decreasing serum cholesterol and attenuation of cardio-toxicity. Curcumin has also shown a significant role in treatment of neurological disorders such as Alzheimer’s disease, Parkinson’s disease and anxiety because it acts on oxidative stress and inflammation-related responses in these diseases that share similar biochemistry. Similarly, it can also inhibit autoimmune diseases by regulating cytokines such as IL-12 and IL-6. Curcuminoids have also been reported to interact with a large number of molecular targets such as signalling molecules, transcription factors, growth factors, receptors, adhesion molecules, pro-inflammatory enzymes and protein kinases.
Molecules 2015, 20(1), 863-878; doi:10.3390/molecules20010863