Mycomed Ingredients – Clinical studies/Trials

Clinical Study-3

Cordyceps Sinensis: A traditional Chinese medicine and another fungal therapeutic biofactory

[Phytochemistry. 2008 May;69(7):1469-95. doi: 10.1016/j.phytochem.2008.01.027. Epub 2008 Mar 17]
Paterson RR1


Traditional Chinese medicines (TCM) are growing in popularity. However, are they effective? Cordyceps is not studied as systematically for bioactivity as another TCM, Ganoderma. Cordyceps is fascinating per se, especially because of the pathogenic lifestyle on Lepidopteron insects. The combination of the fungus and dead insect has been used as a TCM for centuries. However, the natural fungus has been harvested to the extent that it is an endangered species. The effectiveness has been attributed to the Chinese philosophy as propagated by  Yin and Yang and can this be compatible with scientific philosophy. Initial results show es they are. A vast literature exists, The role of the insect has been ignored. Some of the analytical methodologies are poor. Data on the “old” compound cordycepin are still being published: ergosterol and related compounds are reported despite being universal to fungi. There is too much work on crude extracts rather than pure compounds with water and methanol solvents being over-represented in this respect (although methanol is an effective solvent). Excessive speculation exists as to the curative properties. However, there are some excellent pharmacological data and relating to apoptosis. For example, some preparations are active against cancers or diabetes which should be fully investigated. Polysaccharides and secondary metabolites are of particular interest. The use of genuine anamorphic forms in bioreactors is encouraged.

DOI: 10.1016/j.phytochem.2008.01.027
[Indexed for MEDLINE]