Ingredients  of Shimbhala Heart Caps – clinical studies/Trials

Clinical Study-2

Rauwolfia Serpentina  in the Treatment of Hypertension and Anxiety

Integr Med (Encinitas). 2015 June; 14(3): 40–46.

PMCID: PMC4566472


This article has been selected from and cited by other articles in PMC.


Rauwolfia (Rauwolfia serpentina) Apocynaceae family. The Chemical Composition of Rauwolfia reveals  many different phytochemicals, including alcohols, sugars and glycosides, fatty acids, flavonoids, phytosterols, oleoresins, steroids, tannins, and alkaloids. The most important alkaloids found in the plant are indole alkaloids,  such as ajmalidine, ajmaline, ajmalinine, ajmalicine, aricine, canescine, coryanthine, deserpidine, isoajmaline, isoserine, isoserpiline, lankanescine, neoajmaline, papaverine, raubasine, raucaffricine, rauhimbine, rauwolfinine, recanescine, rescinnamine, reserpiline, reserpine, reserpinine, sarpagine, serpentine, serpentinine, thebaine, yohimbine, and yohimbinine. Reserpine is the most widely studied alkaloid found in R serpentina

Mechanism of Action

The mechanism of action of reserpine is well researched and well documented. Reserpine binds to protein receptors called vesicular monamine transporters (VMATs) in the organelle membranes of specialized secretory vesicles of presynaptic neurons. Reserpine prevents intracellular neurotransmitters from binding to VMAT proteins and stops secretory vesicles from uptaking neurotransmitters.

Results of study on Rauwolfia

A  study of 50 patients with essential hypertension who were treated with Rauwolfia.26 In that study, 85% of patients experienced a drop in systolic blood pressure, and 81% of patients experienced a drop in diastolic blood pressure.

Meissner reported Rauwolfia to be effective in 90% of a study’s participants, with a lowering of systolic blood pressure between 15 and 40 mm Hg.26 

Loffler in Switzerland reported a lowering of blood pressure in 51 Swiss workers with hypertension.

Japanese researchers  reported lower blood pressure in 12 of 15 patients with hypertension

Doyle and Smirk in Zealand reported that reserpine produced a striking fall in blood pressure within 4 to 6 hours of administration.

Rauwolfia has also been studied for the treatment of mental diseases, including schizophrenia and bipolar disorder, epilepsy and seizures, and of insomnia and sleep problems.

One study found Rauwolfia to be effective in the treatment of anxiety. All forms of Rauwolfia were used in that study, including reserpine, alseroxylon, and the whole root, and all gave the same results in the control of overt anxiety in ambulatory patients.

One study found that Rauwolfia treated migraine headaches effectively

Most subjects have reported that they feel better and less anxious and nervous. Sleep quality often has been reported better.

The total daily dose of Rauwolfiashould be lower than 500 mg of root and, in most cases, can be less than 250 mg per day.