Ingredients  of Shimbhala Herbal Extracts – clinical studies/Trials

Clinical study – 2 GINGER

A study published in the “South Asian Journal of Preventive Cardiology” in 2004


SK Verma, A Bordia, P Jain, KC Srivastava*

  • Indigenous Drug Research Centre, Department of Medicine, R.N.T. Medical College, Udaipur. India
  • Department of Environmental Medicine*, Odense University, Odense, Denmark.



Ginger contains components with strong anti-platelet, prostanoid synthesis inhibitory activity and antioxidant potential, prompting a detailed study for its antioxidant effect in healthy subjects and in patients with coronary artery disease.

Study Design : Randomised, double blinded, placebo controlled study.

Materials and Methods used in study

Twenty healthy individuals (Group-A) and twenty patients with coronary artery disease (Group-B) were selected. Both the groups were randomly assigned either dry ginger (5gm) or matched placebo (Lactose powder) for four weeks. Blood lipids and lipoprotein oxidation susceptibility were estimated initially and at the end of the study and the results were analysed using paired t-test.


Ginger administration dramatically (P<0.001) decreased lipoprotein oxidation susceptibility in healthy subjects and also in group B patients with coronary artery disease without any effect on blood lipids. No adverse effects were observed.


Ginger has been clinically studied various times for it’s strong free radical scavenging property. This antioxidant potential along with other beneficial effects of ginger makes it a strong contender for its use in patients with ischemic heart disease.

The free radical damaging reaction is responsible for it to be a significant contributor to the process of atherosclerosis, inflammation, cancer and aging. Increasing evidences indicate an inverse correlation between consumption of certain food (containing antioxidants) and incidence of ischemic heart disease (IHD) and Cancer . Many randomized trials of antioxidant vitamins have exhibited equivocal results in patients with IHD . More importantly, a potential harmful effect of synthetic antioxidant vitamins in patients with known or suspected CAD has also been observed . Therefore, the antioxidant property of ginger needs to be given it’s due importance. It has added advantage of being a natural antioxidant, which might prove more useful by providing flavenoids and other antioxidant compounds.