Ingredients of Shimbhala Herbal Extracts – clinical studies/Trials
Clinical study – 4 GARLIC
Aged garlic extract reduces blood pressure in hypertensives: a dose-response trial
Hypertension prevails in atleast 30% of adults population worldwide. Garlic has blood pressure-lowering properties and the mechanism of action is biologically plausible. This trial assessed the effect, dose-response, tolerability and acceptability of different doses of aged garlic extract as an adjunct treatment to existing anti-hypertensive medication in patients with uncontrolled hypertension.
An aggregste of 79 general practice patients with uncontrolled systolic hypertension participated in a double-blind randomised placebo-controlled dose-response trial of 3 months. Subjects were split to one of three garlic groups with either of one, two or four capsules daily of aged garlic extract (240/480/960 mg containing 0.6/1.2/2.4 mg of S-allylcysteine) or placebo. Blood pressure was assessed at 4, 8 and 12 weeks and compared with baseline using a mixed-model approach. Tolerability was monitored throughout the trial and acceptability was assessed at 12 weeks with the help of a questionnaire.
Mean systolic blood pressure was significantly reduced by 11.8±5.4 mm Hg in the garlic-2-capsule group over 12 weeks compared with placebo (P=0.006), and reached borderline significant reduction in the garlic-4-capsule group at 8 weeks (-7.4±4.1 mm Hg, P=0.07). Changes in systolic blood pressure in the garlic-1-capsule group and diastolic blood pressure were not significantly different to placebo. Tolerability, compliance and acceptability was higher amonst all garlic groups (93%) and highest in the groups taking one or two capsules daily.
This pathbreaking clinical trial suggests aged garlic extract to be an effective and tolerable treatment in uncontrolled hypertension and may be considered as a safe adjunct treatment to conventional antihypertensive therapy due to it being considered inert and without any significant side effects.