Ingredients  of Shimbhala Herbal Extracts – clinical studies/Trials

Clinical study – 4 GARLIC

Aged garlic extract reduces blood pressure in hypertensives: a dose-response trial

Ried K1Frank ORStocks NP

Discipline of General Practice, The University of Adelaide, Adelaide, South Australia, Australia. ua.mo1634656964c.mii1634656964n@dei1634656964rnira1634656964k1634656964




Hypertension prevails in atleast  30% of adults population worldwide. Garlic has blood pressure-lowering properties and the mechanism of action is biologically plausible. This trial assessed the effect, dose-response, tolerability and acceptability of different doses of aged garlic extract as an adjunct treatment to existing anti-hypertensive medication in patients with uncontrolled hypertension.


An aggregste of  79 general practice patients with uncontrolled systolic hypertension participated in a double-blind randomised placebo-controlled dose-response trial of 3 months. Subjects were split  to one of three garlic groups with either of one, two or four capsules daily of aged garlic extract (240/480/960 mg containing 0.6/1.2/2.4 mg of S-allylcysteine) or placebo. Blood pressure was assessed at 4, 8 and 12 weeks and compared with baseline using a mixed-model approach. Tolerability was monitored throughout the trial and acceptability was assessed at 12 weeks with the help of a  questionnaire.


Mean systolic blood pressure was significantly reduced by 11.8±5.4 mm Hg in the garlic-2-capsule group over 12 weeks compared with placebo (P=0.006), and reached borderline significant reduction in the garlic-4-capsule group at 8 weeks (-7.4±4.1 mm Hg, P=0.07). Changes in systolic blood pressure in the garlic-1-capsule group and diastolic blood pressure were not significantly different to placebo. Tolerability, compliance and acceptability was higher amonst  all garlic groups (93%) and highest in the groups taking one or two capsules daily.


This pathbreaking clinical  trial suggests aged garlic extract to be an effective and tolerable treatment in uncontrolled hypertension and may be considered as a safe adjunct treatment to conventional antihypertensive therapy due to it being considered inert and without any significant side effects.