Ingredients  of Shimbhala Herbal Extracts – clinical studies/Trials

Clinical study – 5 Honey

Honey–a novel antidiabetic agent

Erejuwa OO1Sulaiman SAWahab MS

Int J Biol Sci. 2012;8(6):913-34

doi: 10.7150/ijbs.3697

Epub 2012 Jul 7



Diabetes mellitus remains the leading life threatening disease worldwide in spite of the availability of numerous anti-diabetic drugs. Honey is a natural substance produced by bees from nectar. Several evidence-based health benefits have been associated  to honey in the recent years. In this study findings which demonstrate the beneficial or potential effects of honey in the gastrointestinal tract (GIT),  on the gut microbiota, in the liver, in the pancreas and how these effects could improve glycemic control and metabolic derangements have been highlighted. In healthy participants or patients with impaired glucose tolerance or diabetes mellitus, various studies revealed that honey reduced blood glucose or was more tolerable than most common sugars or sweeteners. Pre-clinical studies provided more convincing evidence in support of honey as a potential anti-diabetic agent than clinical studies did.


The experimental study was conducted at the Jinnah Medical College Hospital, Karachi, and consisted of 97 type 2 diabetic patients. The patients were randomly divided into 75 gram honey group (group 1), 30 gram honey group (group 2), and 75 gram glucose group (group 3). Fasting blood samples were obtained as well as after 1 and 2 hour. SPSS 11 was used for statistical analysis.


Of the 97 participants, 62 (64%) were females and 35 (36%) males.Their ages ranged from 25-68 years. Mean rise in blood glucose after three hours in group 2 was 30 mg/dl; group 1, 85mg/dl, and group 3, 170 mg/dl. The difference was visibly significant (p <0.005).The glucose response was significantly lower at 3 hours in group 2 (p <0.001) compared to group 1 or group 2. A visible  difference was also seen in group 1 and 3 (p <0.0001). The plasma glucose level in response to honey peaked at 60 min and showed a rapid decline compared to that of glucose, indicating a lower glycaemic response of honey. A minority of patients 3 (10.7%) exhibited  a glucose lowering effect after low dose of honey.


Low dose of honey can be a valuable sugar substitute for patients with diabetes.