Ingredients  of Shimbhala Herbal Extracts – clinical studies/Trials

Clinical study – 7 Lemon

Citrus extracts benefit cardiovascular health in osteoarthritis patients: a double-blind, placebo-controlled pilot study

Oben J1Enonchong EKothari SChambliss WGarrison RDolnick D

Nutr J. 2008 May 20;7:16. doi: 10.1186/1475-2891-7-16




The objective of this clinical study was to assess the potential benefit of Citrus extracts on cardiovascular protective properties in overweight and normal weight adults diagnosed with osteoarthritis of the knee.


An 8-week, placebo-controlled, randomized, double-blind study was conducted with four groups, viewing  effects of Citrus extracts  to placebo in overweight and normal weight subjects diagnosed with primary osteoarthritis .Citrus extracts  or matching placebo was given in a dose of two capsules (370 mg each) twice daily. The outcome measures reported are lipid levels, weight, BMI, blood pressure and fasting glucose. Analyses of variance were used to compare changes of physiological measures over the trial period and between groups.


Eighty (80) subjects were enrolled and 45 subjects completed the study. No serious adverse events were reported. Citrus extracts  administration was associated with a general improvement in lipid levels. Both the overweight and normal weight treatment groups had significant reductions in triglycerides and LDL-cholesterol, as well as a significant increase in HDL-cholesterol compared to others. Overall there were decreases in blood pressure in both overweight and normal weight treatment groups compared to respective placebo groups. There was also a significant decrease in fasting glucose levels in the overweight treatment group compared to the start of the study and to the overweight placebo group. There was no change in fasting blood sugar for the normal weight groups. Both overweight and normal weight treatment groups lost a visible amount of weight compared to their respective placebo groups. The overweight treatment group decreased an average of 5% body weight after 8 weeks, which was also linked with a significant loss in BMI over time.


In this pilot study Citrus extracts  had a beneficial effect on cardiovascular risk factors; namely lipid levels, blood pressure and fasting glucose levels. Administration of Citrus extracts  was also associated with weight loss.